AUTHOR=Piatnitskaia Svetlana , Rafikova Guzel , Bilyalov Azat , Chugunov Svyatoslav , Akhatov Iskander , Pavlov Valentin , Kzhyshkowska Julia TITLE=Modelling of macrophage responses to biomaterials in vitro: state-of-the-art and the need for the improvement JOURNAL=Frontiers in Immunology VOLUME=Volume 15 - 2024 YEAR=2024 URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1349461 DOI=10.3389/fimmu.2024.1349461 ISSN=1664-3224 ABSTRACT=
The increasing use of medical implants in various areas of medicine, particularly in orthopedic surgery, oncology, cardiology and dentistry, displayed the limitations in long-term integration of available biomaterials. The effective functioning and successful integration of implants requires not only technical excellence of materials but also consideration of the dynamics of biomaterial interaction with the immune system throughout the entire duration of implant use. The acute as well as long-term decisions about the efficiency of implant integration are done by local resident tissue macrophages and monocyte-derived macrophages that start to be recruited during tissue damage, when implant is installed, and are continuously recruited during the healing phase. Our review summarized the knowledge about the currently used macrophages-based