AUTHOR=Qi Wenxia , Tian Jiexiang , Wang Gang , Yan Yanfeng , Wang Tao , Wei Yong , Wang Zhandong , Zhang Guohua , Zhang Yuanyuan , Wang Jia 

TITLE=Advances in cellular and molecular pathways of salivary gland damage in Sjögren’s syndrome

JOURNAL=Frontiers in Immunology

VOLUME=Volume 15 - 2024

YEAR=2024

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1405126

DOI=10.3389/fimmu.2024.1405126

ISSN=1664-3224

ABSTRACT=Sjögren's Syndrome (SS) is an autoimmune disorder characterized by dysfunction of exocrine glands. Primarily affected are the salivary glands, whi ch exhibit the most frequent pathological changes. The pathogenesis involves s usceptibility genes, non-genetic factors such as infections, immune cells-includin g T and B cells, macrophage, dendritic cells, and salivary gland epithelial cells. Inflammatory mediators such as autoantibodies, cytokines, and chemokines also play a critical role. Key signaling pathways activated include IFN, TLR, BAF F/BAFF-R, PI3K/Akt/mTOR, among others. Comprehensive understanding of th ese mechanisms is crucial for developing targeted therapeutic interventions. Thu s, this study explores the cellsular and molecular mechanisms underlying SS-rel ated salivary gland damage, aiming to propose novel targeted therapeutic appro aches.