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REVIEW article

Front. Immunol.
Sec. Cancer Immunity and Immunotherapy
Volume 15 - 2024 | doi: 10.3389/fimmu.2024.1410519
This article is part of the Research Topic Prognostic of New Strategies for Treating Children and Young Adults with Acute Lymphoblastic Leukemia View all articles

Acute T-cell lymphoblastic leukemia: Chimeric antigen receptor technology may offer a new hope

Provisionally accepted
Jiajie Jing Jiajie Jing Yuan Ma Yuan Ma *Ziwen Xie Ziwen Xie *Bingyan Wang Bingyan Wang *Yueming Chen Yueming Chen *Enjie Chi Enjie Chi *Jiadong Wang Jiadong Wang *Kejin Zhang Kejin Zhang *Sisi Li Sisi Li *
  • Hangzhou City University, Hangzhou, China

The final, formatted version of the article will be published soon.

    Acute lymphoblastic leukemia (ALL) is a prevalent malignancy affecting the hematopoietic system, encompassing both B-cell ALL (B-ALL) and T-cell ALL (T-ALL). T-ALL, characterized by the proliferation of T-cell progenitors in the bone marrow, presents significant treatment challenges, with patients often experiencing high relapse rates and poor long-term survival despite advances in chemotherapy and hematopoietic stem cell transplantation (HSCT). This review explores the pathogenesis and traditional treatment strategies of T-ALL, emphasizing the promising potential of chimeric antigen receptor (CAR) technology in overcoming current therapeutic limitations. CAR therapy, leveraging genetically modified immune cells to target leukemia-specific antigens, offers a novel and precise approach to T-ALL treatment. The review critically analyzes recent developments in CAR-T and CAR-NK cell therapies, their common targets, optimization strategies, clinical outcomes, and the associated challenges, providing a comprehensive overview of their clinical prospects in T-ALL treatment.

    Keywords: T-ALL, Pathogenesis, Chimeric Antigen Receptor, car-t, CAR-NK

    Received: 01 Apr 2024; Accepted: 15 Jul 2024.

    Copyright: © 2024 Jing, Ma, Xie, Wang, Chen, Chi, Wang, Zhang and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Yuan Ma, Hangzhou City University, Hangzhou, China
    Ziwen Xie, Hangzhou City University, Hangzhou, China
    Bingyan Wang, Hangzhou City University, Hangzhou, China
    Yueming Chen, Hangzhou City University, Hangzhou, China
    Enjie Chi, Hangzhou City University, Hangzhou, China
    Jiadong Wang, Hangzhou City University, Hangzhou, China
    Kejin Zhang, Hangzhou City University, Hangzhou, China
    Sisi Li, Hangzhou City University, Hangzhou, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.