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SYSTEMATIC REVIEW article
Front. Immunol.
Sec. Cancer Immunity and Immunotherapy
Volume 15 - 2024 |
doi: 10.3389/fimmu.2024.1413858
This article is part of the Research Topic Exploring Novel Immunotherapy Targets and Combinational Immunotherapy in Breast and Gastrointestinal Cancers View all 11 articles
Application and prospect of organoid technology in breast cancer
Provisionally accepted- 1 Department of Breast and Thyroid Surgery, Southwest Hospital, Army Medical University, Chongqin, China
- 2 Key laboratory of Chongqing Health Commission for Minimally Invasive and Precise Diangnosis and Treatment of Breast cancer, Chongqing, China
Breast cancer is the most common malignant tumor in women. Due to the high heterogeneity of breast cancer cells, traditional in vitro research models still have major limitations. Therefore, it is urgent to establish an experimental model that can accurately simulate the characteristics of human breast cancer. Breast cancer organoid technology emerged as the times required, that is, to construct tissue analogs with organ characteristics by using a patient's tumor tissue through 3D culture in vitro. Since the breast cancer organoid can fully preserve the histology and genetic characteristics of the original tumor, it provides a reliable model for preclinical drug screening, establishment of breast cancer organoid biobanks, research into the mechanisms of tumor development, and determination of cancer targets. It has promoted personalized treatment for clinical breast cancer patients. This article mainly focuses on recent research progress and applications of organoid technology in breast cancer, discussing the current limitations and prospects of breast cancer organoid technology.
Keywords: Organoids, breast cancer, drug screening, personalized treatment, tumor research models
Received: 08 Apr 2024; Accepted: 06 Aug 2024.
Copyright: © 2024 Qi, Huang, Mei, Wan and Zhao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Xiaowei Qi, Department of Breast and Thyroid Surgery, Southwest Hospital, Army Medical University, Chongqin, 400038, China
Shanlin Huang, Department of Breast and Thyroid Surgery, Southwest Hospital, Army Medical University, Chongqin, 400038, China
Zifan Mei, Department of Breast and Thyroid Surgery, Southwest Hospital, Army Medical University, Chongqin, 400038, China
Andi Wan, Department of Breast and Thyroid Surgery, Southwest Hospital, Army Medical University, Chongqin, 400038, China
Min Zhao, Department of Breast and Thyroid Surgery, Southwest Hospital, Army Medical University, Chongqin, 400038, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Shanlin Huang
1,2*