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MINI REVIEW article

Front. Immunol.
Sec. Multiple Sclerosis and Neuroimmunology
Volume 15 - 2024 | doi: 10.3389/fimmu.2024.1441733
This article is part of the Research Topic Regulation of neuroinflammation and brain aging by microRNAs View all articles

MiRNA-based therapeutic potential in multiple sclerosis

Provisionally accepted
  • 1 Center for Multiple Sclerosis of Catalonia, Vall d'Hebron University Hospital, Barcelona, Catalonia, Spain
  • 2 Vall d'Hebron University Hospital, Barcelona, Catalonia, Spain
  • 3 University of Vic - Central University of Catalonia, Barcelona, Catalonia, Spain

The final, formatted version of the article will be published soon.

    This review will briefly introduce microRNAs (miRNAs) and dissect their contribution to multiple sclerosis (MS) and its clinical outcomes. For this purpose, we provide a concise overview of the present knowledge of MS pathophysiology, biomarkers and treatment options, delving into the role of selectively expressed miRNAs in clinical forms of this disease, as measured in several biofluids such as serum, plasma or cerebrospinal fluid (CSF). Additionally, up-to-date information on current strategies applied to miRNA-based therapeutics will be provided, including miRNA restoration therapy (lentivirus expressing a specific type of miRNA and miRNA mimic) and miRNA inhibition therapy such as antisense oligonucleotides, small molecules inhibitors, locked nucleic acids (LNAs), anti-miRNAs, and antagomirs. Finally, it will highlight future directions and potential limitations associated with their application in MS therapy, emphasizing the need for improved delivery methods and validation of therapeutic efficacy.

    Keywords: MicroRNAs, Multiple Sclerosis, Neurology, biomarkers, therapeutic targets

    Received: 31 May 2024; Accepted: 13 Aug 2024.

    Copyright: © 2024 Zabalza, Pappolla, Comabella, Montalban and Malhotra. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Sunny Malhotra, Vall d'Hebron University Hospital, Barcelona, 08035, Catalonia, Spain

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.