AUTHOR=Robertoni Fabíola Santos Zambon , Velosa Ana Paula Pereira , Oliveira Luana de Mendonça , Almeida Francine Maria de , Silveira Lizandre Keren Ramos da , Queiroz Zelita Aparecida de Jesus , Lobo Thays de Matos , Contini Vitória Elias , Baldavira Camila Machado , Carrasco Solange , Fernezlian Sandra de Morais , Sato Maria Notomi , Capelozzi Vera Luiza , Lopes Fernanda Degobbi Tenorio Quirino dos Santos , Teodoro Walcy Paganelli Rosolia TITLE=Type V collagen-induced nasal tolerance prevents lung damage in an experimental model: new evidence of autoimmunity to collagen V in COPD JOURNAL=Frontiers in Immunology VOLUME=Volume 15 - 2024 YEAR=2024 URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1444622 DOI=10.3389/fimmu.2024.1444622 ISSN=1664-3224 ABSTRACT=Chronic obstructive pulmonary disease (COPD) has been linked to immune responses to lung-associated self-antigens. Exposure to cigarette smoke (CS), the main cause of COPD, causes chronic lung inflammation, resulting in pulmonary matrix (ECM) damage. This tissue breakdown exposes collagen V (Col V), an antigen typically hidden from the immune system, which could trigger an autoimmune response. Col V autoimmunity has been linked to several lung diseases, and the induction of immune tolerance can mitigate some of these diseases. Evidence suggests that autoimmunity to Col V might also occur in COPD; thus, immunotolerance to Col V could be a novel therapeutic approach.