AUTHOR=Da Xue , Juan Zhang , Zhijun Hu , Zhongchuan Lyu 

TITLE=Case report: Significant response of alpha-fetoprotein-producing gastric cancer from combined chemotherapy and immunotherapy

JOURNAL=Frontiers in Immunology

VOLUME=Volume 15 - 2024

YEAR=2024

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1448875

DOI=10.3389/fimmu.2024.1448875

ISSN=1664-3224

ABSTRACT=Alpha-fetoprotein-producing gastric cancer (AFPGC) represents a particularly aggressive subtype of gastric carcinoma characterised by elevated rates of vascular invasion ［ 1 ］ , lymphatic dissemination, hepatic metastasis, and an unfavourable clinical outcome ［ 2 ］ .Treatment strategies for AFPGC have historically lacked specificity. Herein, a case is presented involving AFPGC in which the patient exhibited a notable response to combined anti-PD-1 antibody immunotherapy and SOX chemotherapy, potentially achieving a cure.