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ORIGINAL RESEARCH article
Front. Immunol.
Sec. Inflammation
Volume 15 - 2024 |
doi: 10.3389/fimmu.2024.1449158
This article is part of the Research Topic Exploring Cardiovascular and Cerebrovascular Diseases Interaction with Inflammation: Biomarkers, Drug Targets, and Personalized Treatments through Multi-omics Data Integration View all 3 articles
Identification of Ribosome Biogenesis Genes and subgroups in Ischaemic Stroke
Provisionally accepted- 1 School of Medicine, Guangxi University, Nanning, China
- 2 College of Life Sciences, Northwest University, Xi'an, Shaanxi, China
- 3 Guangxi University, Nanning, China
- 4 Department of General Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
Globally, ischaemic stroke is a leading cause of death and severe disability. Given the importance of protein synthesis in the inflammatory response and neuronal repair and regeneration after stroke, and that proteins are acquired through ribosomal translation of mRNA, it has been theorised that ribosome biogenesis may have an impact on promoting and facilitating recovery after stroke.However, the relationship between stroke and ribosome biogenesis has not been investigated. In the present study, a ribosome biogenesis gene signature (RSG) was developed using Cox and least absolute shrinkage and selection operator (LASSO) analysis. We obtained a set of 12 ribosome biogenesis-related genes (EXOSC5, MRPS11, MRPS7, RNASEL, RPF1, RPS28, C1QBP, GAR1, GRWD1, PELP1, UTP, ERI3), which play a key role in assessing the prognostic risk of ischaemic stroke. We used the above 12 genes to stratify ischaemic stroke patients into high-risk and low-risk groups, and further elucidated the immune infiltration of the disease using ssGSEA, which clarified the close relationship between ischaemic stroke and immune subgroups. Importantly, risk grouping using ribosome biogenesis-related genes was also closely associated with important signaling pathways in stroke. Through bioinformatics analysis, we identified potential IS-RSGs and explored future therapeutic targets, thereby facilitating the development of more effective therapeutic strategies and novel drugs against potential therapeutic targets in ischaemic stroke.
Keywords: Ribosome biogenesis, Stroke, CIBERSORT, Immune infiltration, Neutrophil
Received: 14 Jun 2024; Accepted: 14 Aug 2024.
Copyright: © 2024 Wang, Zhang, Nanqing, Qingfeng and He. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Chen Qingfeng, Guangxi University, Nanning, China
Zehua He, Department of General Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
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