AUTHOR=Wang Jia , Zheng Haotao , Wei Jia , Wu Jiaping , Feng Ziyang , Chen Xueqin , Liu Yangsicheng , Qin Wenxin , Qin Xiude , Kong Fanxin 

TITLE=Telitacicept in combination with B-cell depletion therapy in MuSK antibody-positive myasthenia gravis: a case report and literature review

JOURNAL=Frontiers in Immunology

VOLUME=Volume 15 - 2024

YEAR=2024

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1456822

DOI=10.3389/fimmu.2024.1456822

ISSN=1664-3224

ABSTRACT=Muscle-specific kinase (MuSK) myasthenia gravis (MG) is relatively rare and has a higher incidence of myasthenic crisis compared with other subtypes. However, there is still a lack of effective treatment for refractory MuSK MG. We report the case of a 70-year-old female MuSK MG patient with recurrent fluctuations who stabilized on telitacicept in combination with anti-CD20 B-cell depletion therapy. This combination regimen deserves further investigation. Furthermore, we summarized the treatment protocols of 14 previously reported cases of MuSK MG.