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MINI REVIEW article
Front. Immunol.
Sec. T Cell Biology
Volume 15 - 2024 |
doi: 10.3389/fimmu.2024.1457771
This article is part of the Research Topic Community Series in the Role of CD1- and MR1-restricted T cells in Immunity and Disease: Volume II View all 14 articles
Comparative assessment of autologous and allogeneic iNKT cell transfer in iNKT cell-based immunotherapy
Provisionally accepted- 1 Department of Medical Immunology, Graduate school of Medicine, Chiba University, Chiba/Japan, Japan
- 2 Chiba University, Chiba, Japan
Invariant natural killer T (iNKT) cells are a small subset of T lymphocytes that release large amounts of cytokines such as IFN-γ and exhibit cytotoxic activity upon activation, inducing strong anti-tumor effects. Harnessing the anti-tumor properties of iNKT cells, iNKT cell-based immunotherapy has been developed to treat cancer patients. In one of the iNKT cell-based immunotherapies, two approaches are utilized, namely, active immunotherapy or adoptive immunotherapy, the latter involving the ex vivo expansion and subsequent administration of iNKT cells. There are two sources of iNKT cells for adoptive transfer, autologous and allogeneic, each with its own advantages and disadvantages. Here, we assess clinical trials conducted over the last decade that have utilized iNKT cell adoptive transfer as iNKT cell-based immunotherapy, categorizing them into two groups based on the use of autologous iNKT cells or allogeneic iNKT cells.
Keywords: invariant natural killer T cells, Adoptive immunotherapy, cancer immunotherapy, Allogeneic cells, induced pluripotent stem cell
Received: 01 Jul 2024; Accepted: 02 Aug 2024.
Copyright: © 2024 Takami and Motohashi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Shinichiro Motohashi, Chiba University, Chiba, Japan
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