AUTHOR=Ahmad Rowaid , Huang Yumeng , Wang Peter R. , Masel Todd , Li Xiangping 

TITLE=Case report: Refractory focal motor seizure associated with cerebrospinal fluid neurochondrin antibody

JOURNAL=Frontiers in Immunology

VOLUME=Volume 15 - 2024

YEAR=2024

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1459119

DOI=10.3389/fimmu.2024.1459119

ISSN=1664-3224

ABSTRACT=The Neurochondrin-associated neurological disorder is rare and its principal clinical manifestations observed so far are cerebellar ataxia, rhombencephalitis, and hyperkinetic movements such as chorea. Neurochondrin antibody-associated Autoimmune Epilepsy (AE) has not been previously reported in the literature. This is the first reported case of refractory autoimmune epilepsy with positive CSF anti-neurochondrin antibody. This study reveals an under-recognized role of neurochondrin antibody in epilepsy.