AUTHOR=Sun Yuxiao , Zhang Yifei , Yang Yuchuan , Liu Weihao , Yin Detao 

TITLE=Coagulation-related genes for thyroid cancer prognosis, immune infltration, staging, and drug sensitivity

JOURNAL=Frontiers in Immunology

VOLUME=Volume 15 - 2024

YEAR=2024

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1462755

DOI=10.3389/fimmu.2024.1462755

ISSN=1664-3224

ABSTRACT=Thyroid cancer (THCA) is the most common endocrine tumor. Coagulation may be associated with the development of cancer, but its role in THCA patients is not yet clear. In this study, we determined the predictive value of coagulation biomarker D-dimer for THCA patient lateral lymph node metastasis (LLNM) through receiver operating characteristics (ROC) analysis and logistic regression analysis.Subsequently, this study used the TCGA database to identify coagulation-related molecular subtypes through consensus clustering analysis and compared their prognosis. We identified coagulation-related genes (CRGs) associated with prognosis in thyroid cancer through gene expression data and clinical information, and constructed a prognostic model by selecting 8 prognostic CRGs using LASSO regression. Patients were divided into high-risk and low-risk groups. The prognosis of low-risk group patients was significantly better than that of high-risk group (P ＜ 0.001). The results showed significant differences in clinical characteristics, gene mutation occurrence, immune infiltration, function, and drug sensitivity between the high-risk and low-risk groups. We also constructed a nomogram combining the model and clinical features to predict the 3-, 5-, and 7-year survival probabilities of patients for better application of this prognostic model. We also validated by qPCR that these 8 prognostic CRGs were overexpressed in THCA cell lines. Overall, this study provided an in-depth exploration of the potential role of the coagulation in thyroid cancer and its clinical significance, offering a new theoretical basis and research direction for personalized therapy and prognostic evaluation.