AUTHOR=Du Yang , Wang Weidong , Zhang Lili , Li Yuan , Chen Xiang , Yang Hui , Ding Xin 

TITLE=Case report on anti-GQ1b antibody syndrome: initial symptoms of pupil palsy and periorbital pain

JOURNAL=Frontiers in Immunology

VOLUME=Volume 15 - 2024

YEAR=2024

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1474354

DOI=10.3389/fimmu.2024.1474354

ISSN=1664-3224

ABSTRACT=Anti-GQ1b antibody syndrome is a spectrum of autoimmune disorders affecting nervous systems. We report a case of a 53-year-old woman presenting mydriasis with acute onset of periorbital pain, photophobia, and subsequently, diplopia. Despite weakly positive anti-GQ1b IgG antibody, the patient exhibited atypical features with isolated ophthalmoplegia and absence of classic Miller-Fisher syndrome triad. Symptoms improved spontaneously without specific immunotherapy. This case highlights the variable clinical presentations of anti-GQ1b antibody syndrome, emphasizing the importance of considering this diagnosis in patients with unexplained iris abnormalities and ophthalmoplegia.