AUTHOR=Guo Dandan , Yan Junchen , Yang Zhenyu , Chen Mengzhu , Zhong Weibo , Yuan Xingxing , Yu Siming 

TITLE=The immune regulatory role of exosomal miRNAs and their clinical application potential in heart failure

JOURNAL=Frontiers in Immunology

VOLUME=Volume 15 - 2024

YEAR=2024

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1476865

DOI=10.3389/fimmu.2024.1476865

ISSN=1664-3224

ABSTRACT=Heart failure (HF) is a complex and debilitating condition characterized by the heart’s inability to pump blood effectively, leading to significant morbidity and mortality. The abnormality of immune response is a key factor in the progression of HF, contributing to adverse cardiac remodeling and dysfunction. Exosomal microRNAs (miRNAs) play a pivotal role in regulating gene expression and cellular function, which are integral to the crosstalk between cardiac and immune cells, influencing immune cell functions, such as macrophage polarization, T cell activity, and cytokine production, thereby modulating various pathological processes of HF, such as inflammation, fibrosis, and cardiac dysfunction. This review emphasizes the immune-regulatory role of exosomal miRNAs in HF and highlights their clinical potential as diagnostic biomarkers and therapeutic agents.