AUTHOR=Lian Yong-qi , Li Peng-fei , Guo Yan , Tao Yan-lin , Liu Ya-nan , Liang Zhao-yu , Zhu Shu-fen 

TITLE=Interaction between ischemia-reperfusion injury and intestinal microecology in organ transplantation and its therapeutic prospects

JOURNAL=Frontiers in Immunology

VOLUME=Volume 15 - 2024

YEAR=2024

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1495394

DOI=10.3389/fimmu.2024.1495394

ISSN=1664-3224

ABSTRACT=Organ transplantation is a vital intervention for end-stage organ failure; however, ischemia-reperfusion injury is a complication of transplantation, affecting the prognosis and survival of transplant recipients. As a complex ecosystem, recent research has highlighted the role of the intestinal microecology in transplantation, revealing its significant interplay with ischemia-reperfusion injury. This review explores the interaction between ischemia-reperfusion injury and intestinal microecology, with a special focus on how ischemia-reperfusion injury affects intestinal microecology and how these microecological changes contribute to complications after organ transplantation, such as infection and rejection. Based on a comprehensive analysis of current research advances, this study proposes potential strategies to improve transplant outcomes, offering guidance for future research and clinical practice.