AUTHOR=Zhao Xuan , Liu Yanfen , Qin Guohui , Ge Yan , Li Qinglong , Chen Xinfeng , Tian Ximei , Yu Yong , Ren Jiangtao , Zhang Yi 

TITLE=Pseudoprogression in CAR-T cell therapy for solid tumor: Case report

JOURNAL=Frontiers in Immunology

VOLUME=Volume 15 - 2024

YEAR=2025

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1504104

DOI=10.3389/fimmu.2024.1504104

ISSN=1664-3224

ABSTRACT=We reported the pseudoprogression in an elderly patient with advanced gastric cancer after chimeric antigen receptor (CAR)-T cell therapy. The hepatic metastases enlarged 1 month after CAR-T cell infusion and then shrunk the next month as seen through computed tomography scanning. Based on a comprehensive evaluation that includes imaging, pathology, serum tumor markers, and clinical symptoms, we arrived at a diagnosis of pseudoprogression after CAR-T cell therapy, which has not been reported in previous studies. In this report, we provide detailed descriptions of the patient’s clinical presentation, imaging findings, treatment process, and follow-up outcomes. We believe that this case holds important implications for CAR-T cell therapy research and offers valuable insights for clinical practice.