AUTHOR=Lamure Sylvain , Chavez Houria Hendel , de Goër de Herve Marie-Ghislaine , Fornecker Luc-Matthieu , Drenou Bernard , Jacquet Caroline , Merabet Fatiha , Kohn Milena , Quélin Florence , Jackson Angela , Choquet Sylvain , Duléry Rémy , Taoufik Yassine , Besson Caroline 

TITLE=Lymphoma patients treated with anti-CD20 and chemotherapy display disconnected T and B cell responses to COVID-19 vaccine

JOURNAL=Frontiers in Immunology

VOLUME=Volume 15 - 2024

YEAR=2025

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1524813

DOI=10.3389/fimmu.2024.1524813

ISSN=1664-3224

ABSTRACT=Due to immunosuppressive treatment, COVID-19 vaccination is challenging in patients with B-cell lymphoma. We prospectively evaluated CD4, CD8 T-cell and serological responses to the COVID-19 mRNA vaccine in a cohort of patients treated for a B-cell lymphoma with anti-CD20 therapy. During lymphoma treatment, CD4, CD8, and CD19 cell dropped. While functional-specific CD4 and CD8 T-cell responses to SARS-CoV-2 were unaffected, vaccination in patients on treatment induced low specific antibody titers, contrasting with a preserved serological response when vaccination was completed before treatment initiation. Those findings reinforce a vaccinal strategy based on completion before lymphoma treatment, with a booster administered afterward.