AUTHOR=Zhang Pei , Shi Kai-li , Gao Chun-lin , Xu Feng , Jia Li-li , Sun Ji-chao 

TITLE=Complement in anti-glomerular basement membrane glomerulonephritis

JOURNAL=Frontiers in Immunology

VOLUME=Volume 16 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2025.1442955

DOI=10.3389/fimmu.2025.1442955

ISSN=1664-3224

ABSTRACT=Anti-glomerular basement membrane glomerulonephritis (anti-GBM GN) is a rare autoimmune disease that often progresses to end-stage renal disease (ESRD). Complement activation and anti-GBM GN are closely related, as evidenced by the renal pathological characteristics of patients with anti-GBM GN, which include the linear deposition of immunoglobulin G (IgG) and C3 along the GBM. Increasing evidence suggests that all three pathways of complement activation may be involved in the pathogenesis and progression of anti-GBM GN. Anti-GBM GN’s clinical symptoms are linked to complement-related proteins, which are risk factors that impact the disease’s prognosis. This suggests that complement activation and activity may be the primary causes of renal damage in anti-GBM GN. Therefore, biomarkers of complement activation can identify anti-GBM GN cases that may progress to severe renal damage, and complement inhibition may become a new strategy for the clinical treatment of anti-GBM GN.