AUTHOR=Hermann Sabine , Althaus Karina , Mustafi Migdat , Mayer Beate , Rosenberger Peter , Haeberle Helene Anna , Bernard Alice 

TITLE=A hyper-acute immune hemolytic anemia induced by contrast medium was successfully treated with eculizumab: a case report

JOURNAL=Frontiers in Immunology

VOLUME=Volume 16 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2025.1464014

DOI=10.3389/fimmu.2025.1464014

ISSN=1664-3224

ABSTRACT=Contrast medium is frequently associated with allergic reactions and kidney dysfunction. However, contrast media can induce hemolytic anemia with a broad spectrum of hemolytic manifestations. We report a 38-year-old patient with very severe immune hemolytic anemia after the application of iomeprol due to a CT of the thorax/abdomen. In this case report, we illustrate the diagnostics and treatment of life-threatening hemolytic anemia induced by a contrast medium that was successfully treated with eculizumab.