AUTHOR=Cheng Le , Luo Peiyue , Li Wei , Chen Qi , Gan Lifeng , Zhang Fangtao , Zheng Liying , Qian Biao 

TITLE=Research progress of extracellular vesicles in the pathogenesis of type IIIA chronic prostatitis

JOURNAL=Frontiers in Immunology

VOLUME=Volume 16 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2025.1496055

DOI=10.3389/fimmu.2025.1496055

ISSN=1664-3224

ABSTRACT=Chronic prostatitis is a prevalent urological condition that significantly impacts patients’ quality of life. Advances in the study of Extracellular Vesicles (EV) have revealed their close involvement in the pathogenesis of prostatitis. This paper reviews the progress in understanding the role of EV in the pathogenesis of chronic prostatitis type IIIA, particularly their involvement in inflammatory responses, cell signaling, and interactions with immune cells. Additionally, it explores the potential applications of EV as drug delivery vehicles, including the targeted delivery of anti-inflammatory agents and immunomodulators, and highlights the challenges associated with developing exosome-based therapeutic strategies. In-depth research on EV holds promise for offering new insights into the diagnosis and treatment of inflammatory diseases.