AUTHOR=Liu Ran , Jiang Xinyan , Dong Ruijuan , Zhang Yuting , Gai Cong , Wei Peng TITLE=Revealing the mechanisms and therapeutic potential of immune checkpoint proteins across diverse protein families JOURNAL=Frontiers in Immunology VOLUME=Volume 16 - 2025 YEAR=2025 URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2025.1499663 DOI=10.3389/fimmu.2025.1499663 ISSN=1664-3224