AUTHOR=Liu Sidi , Liu Yang , Li Ming , Shang Shuangshuang , Cao Yunxiang , Shen Xi , Huang Chuanbing 

TITLE=Artificial intelligence in autoimmune diseases: a bibliometric exploration of the past two decades

JOURNAL=Frontiers in Immunology

VOLUME=Volume 16 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2025.1525462

DOI=10.3389/fimmu.2025.1525462

ISSN=1664-3224

ABSTRACT=ObjectiveAutoimmune diseases have long been recognized for their intricate nature and elusive mechanisms, presenting significant challenges in both diagnosis and treatment. The advent of artificial intelligence technology has opened up new possibilities for understanding, diagnosing, predicting, and managing autoimmune disorders. This study aims to explore the current state and emerging trends in the field through bibliometric analysis, providing guidance for future research directions.MethodsThe study employed the Web of Science Core Collection database for data acquisition and performed bibliometric analysis using CiteSpace, HistCite Pro, and VOSviewer.ResultsOver the past two decades, 1,695 publications emerged in this research field, including 1,409 research articles and 286 reviews. This investigation unveils the global development landscape predominantly led by the United States and China. The research identifies key institutions, such as Brigham & Women’s Hospital, influential journals like the Annals of the Rheumatic Diseases, distinguished authors including Katherine P. Liao, and pivotal articles. It visually maps out the research clusters’ evolutionary path over time and explores their applications in patient identification, risk factors, prognosis assessment, diagnosis, classification of disease subtypes, monitoring and decision support, and drug discovery.ConclusionAI is increasingly recognized for its potential in the field of autoimmune diseases, yet it continues to face numerous challenges, including insufficient model validation and difficulties in data integration and computational power. Significant advancements have been demanded to enhance diagnostic precision, improve treatment methodologies, and establish robust frameworks for data protection, thereby facilitating more effective management of these complex conditions.