AUTHOR=Zhao Guowang , Li Xinghai , Zhang Ying , Wang Xingzi , Deng Li , Xu Juan , Jin Shumei , Zuo Zan , Xun Linting , Luo Mei , Yang Fan , Qi Jialong , Fu Ping 

TITLE=Intricating connections: the role of ferroptosis in systemic lupus erythematosus

JOURNAL=Frontiers in Immunology

VOLUME=Volume 16 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2025.1534926

DOI=10.3389/fimmu.2025.1534926

ISSN=1664-3224

ABSTRACT=Systemic lupus erythematosus (SLE) is a chronic inflammatory and autoimmune disease with multiple tissue damage. However, the pathology remains elusive, and effective treatments are lacking. Multiple types of programmed cell death (PCD) implicated in SLE progression have recently been identified. Although ferroptosis, an iron-dependent form of cell death, has numerous pathophysiological features similar to those of SLE, such as intracellular iron accumulation, mitochondrial dysfunction, lipid metabolism disorders and concentration of damage associated-molecular patterns (DAMPs), only a few reports have demonstrated that ferroptosis is involved in SLE progression and that the role of ferroptosis in SLE pathogenesis continues to be neglected. Therefore, this review elucidates the potential intricate relationship between SLE and ferroptosis to provide a reliable theoretical basis for further research on ferroptosis in the pathogenesis of SLE.