AUTHOR=Yang Heqi , Ma Yuhang , Zhang Chenyan , Leng Qingqing , Cheng Ke , Zhao Chengjian , Cao Dan TITLE=Case Report: Combined PD-1 and tyrosine kinase blockade stabilizes refractory pancreatic cancer guided by the spatial structure of tumor immune microenvironment JOURNAL=Frontiers in Immunology VOLUME=Volume 16 - 2025 YEAR=2025 URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2025.1547388 DOI=10.3389/fimmu.2025.1547388 ISSN=1664-3224