AUTHOR=Li Sijin , Zhou Yusi , Wang Hairong , Qu Gexi , Zhao Xuan , Wang Xu , Hou Rui , Guan Zhangchun , Liu Dan , Zheng Junnian , Shi Ming TITLE=Advances in CAR optimization strategies based on CD28 JOURNAL=Frontiers in Immunology VOLUME=Volume 16 - 2025 YEAR=2025 URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2025.1548772 DOI=10.3389/fimmu.2025.1548772 ISSN=1664-3224