AUTHOR=Fu Miaoxin , Lv Mingzhu , Guo Jinyue , Mei Aihua , Qian Hang , Yang Handong , Wu Wenwen , Liu Zhixin , Zhong Jixin , Wei Ying , Min Xinwen , Wu Haiyan , Chen Jun 

TITLE=The clinical significance of T-cell regulation in hypertension treatment

JOURNAL=Frontiers in Immunology

VOLUME=Volume 16 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2025.1550206

DOI=10.3389/fimmu.2025.1550206

ISSN=1664-3224

ABSTRACT=Hypertension, a globally prevalent condition, is closely associated with T cell-mediated inflammatory responses. Studies have shown that T cells, by secreting pro-inflammatory cytokines such as interferon-gamma (IFN-γ), Interleukin-17 (IL-17), and Tumor necrosis factor-alpha (TNF-α), directly lead to vascular dysfunction and elevated blood pressure. The activation of Th1 and Th17 cell subsets, along with the dysfunction of regulatory T cells (Tregs), is a critical mechanism in the onset and progression of hypertension. This review explores the role of T cells in the pathophysiology of hypertension and discusses potential therapeutic strategies targeting T cell regulation, such as immunotherapy and gene-editing technologies. These emerging treatments hold promise for providing personalized therapeutic options for hypertensive patients, reducing inflammatory complications, and improving treatment outcomes.