AUTHOR=Guan Xiaoqing , Zhang Fengyi , Zhang Ning , Li Guangchun , Yin Fei 

TITLE=Roles of METTL3 and NLRP3 in pyroptosis and prospects in SCIRI

JOURNAL=Frontiers in Immunology

VOLUME=Volume 16 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2025.1552704

DOI=10.3389/fimmu.2025.1552704

ISSN=1664-3224

ABSTRACT=Spinal cord ischemia-reperfusion injury (SCIRI) leads to severe neurological deficits, with pyroptosis emerging as a key driver of inflammation and neuronal death. Recent studies suggest that methyltransferase-like 3 (METTL3), a critical RNA methyltransferase, may regulate the nucleotide-binding oligomerized structural domain-like receptor protein 3 (NLRP3) inflammasome activation via N6-Methyladenosine (m6A) modification, yet direct evidence in SCIRI remains limited. This review synthesizes current knowledge on the METTL3-NLRP3 axis in pyroptosis, explores its therapeutic potential, and identifies critical research gaps for future investigation.