AUTHOR=Lin Wulian , Wu Cuiling , Xu Guilin , Yi Gaocheng , Zhang Guanpo , Li Haitao , Zheng Jin , Li Dazhou , Wang Wen 

TITLE=Multiple gastric tumors in patients with combined autoimmune and helicobacter pylori-associated gastritis: a case report and literature review

JOURNAL=Frontiers in Immunology

VOLUME=Volume 16 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2025.1562853

DOI=10.3389/fimmu.2025.1562853

ISSN=1664-3224

ABSTRACT=This paper presents four cases of autoimmune gastritis coexisting with Helicobacter pylori- associated gastritis, all of which developed gastric tumors, with some cases exhibiting multiple histological origins. Through a narrative literature review, we explore the potential mechanisms and clinical implications of tumor development in this context. This report emphasizes the significance of recognizing synergistic mucosal injury in chronic gastritis management and highlights the need for future studies into combined pathogenesis.