AUTHOR=Hou Xin-Yi , Xiao Hai-Lu , Wang Jing-Yu , Zhang Jin , Ren Bo , Niu Chu-chu , Liu Fei-Fei , Lu Bin 

TITLE=Spesolimab in generalized pustular psoriasis complicated by acrodermatitis continua of Hallopeau: a case report and mechanistic insights

JOURNAL=Frontiers in Immunology

VOLUME=Volume 16 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2025.1563553

DOI=10.3389/fimmu.2025.1563553

ISSN=1664-3224

ABSTRACT=A 62-year-old Chinese woman presented to the hospital for help with generalized pustular psoriasis (GPP) and acrodermatitis continua of Hallopeau (ACH). While conventional treatments failed to achieve significant improvement, the patient received two doses of spesolimab, and the effect was remarkable. No adverse reactions were observed in the follow-up period.