AUTHOR=Liang Shanshan , Xu Wei , Zhong Peiying , Tao Chuanmin , Zhang Li , Jia Chengyao 

TITLE=Case Report: IgG4-RD-related ophthalmopathy combined with monoclonal gammopathy of undetermined significance

JOURNAL=Frontiers in Immunology

VOLUME=Volume 16 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2025.1565388

DOI=10.3389/fimmu.2025.1565388

ISSN=1664-3224

ABSTRACT=IgG4-related disease (IgG4-RD), an immune-mediated fibroinflammatory disorder, has few reports in combination with monoclonal gammopathy of undetermined significance (MGUS). Herein, we present a case of a 69-year-old woman with manifestations of left orbital occupation and visual acuity decline. Ancillary tests indicated persistent positivity of IgG4 antibody, and IgG4-RD-related ophthalmopathy was diagnosed based on the criteria. Concurrently, serum protein electrophoresis revealed an M protein level of 12.23 g/L. Immunofixation electrophoresis suggested a positive IgG λ-type M protein, and MGUS was diagnosed in conjunction with bone marrow smear and flow cytometry.