AUTHOR=Sau Antonella , Di Prinzio Gianfranco , Onofrillo Daniela , Russo Anna Caterina , Santoro Nicole , Di Ianni Mauro 

TITLE=Case Report: A case of pediatric persistent refractory ITP responsive to avatrombopag

JOURNAL=Frontiers in Immunology

VOLUME=Volume 16 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2025.1576053

DOI=10.3389/fimmu.2025.1576053

ISSN=1664-3224

ABSTRACT=Immune thrombocytopenia (ITP) is a rare hematologic disorder characterized by low platelet counts due to an immune-mediated destruction of platelets. While corticosteroids, intravenous immunoglobulin (IVIG) are the mainstays of treatment, a subset of patients may remain refractory to these therapies. Here, we present a case of a 6-year-old girl diagnosed with refractory ITP, who failed to respond to standard therapies but showed a remarkable clinical improvement with avatrombopag, a thrombopoietin receptor agonist.