AUTHOR=Sun Xuan , Wang Jiayan , Gu Hao , Guo Maojuan , Yang Zhen 

TITLE=Uncovering a new mechanism of ischemic stroke: a study of the association between γδ T cells and immunoinflammation

JOURNAL=Frontiers in Immunology

VOLUME=Volume 16 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2025.1583274

DOI=10.3389/fimmu.2025.1583274

ISSN=1664-3224

ABSTRACT=Ischemic stroke, characterized by high clinical mortality and poor prognosis, has been prioritized by the World Health Organization (WHO) for reducing the burden of non-communicable diseases. However, the pathogenesis of ischemic stroke remains complex and poorly understood. Recent studies have revealed the infiltration of γδ T cells within ischemic stroke lesions, accompanied by the upregulation of IL-17, IL-23, and other inflammatory cytokines, suggesting their involvement in the stroke’s pathological process. Literature indicates that γδ T cells are recruited to the lesion site by microglia-derived chemokines and subsequently infiltrate the damaged brain tissue. This review summarizes current knowledge on the precise mechanisms underlying γδ T cell activation, migration, and ensuing immune-inflammatory responses in neuroinflammation, as well as their role in the progression of ischemic stroke. It further discusses the therapeutic potential of targeting γδ T cells to modulate neuroinflammation for ischemic stroke treatment, thereby offering novel therapeutic targets for managing neuroinflammation in this condition.