AUTHOR=Salas Sánchez Marta , García-Martínez Elena , Balastegui Martín Héctor , Durán-García María Esther , Lavilla Olleros Cristina 

TITLE=Use of anakinra in cryopyrin-associated periodic syndromes: case report and review of literature

JOURNAL=Frontiers in Immunology

VOLUME=Volume 16 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2025.1591234

DOI=10.3389/fimmu.2025.1591234

ISSN=1664-3224

ABSTRACT=Cryopyrin-associated periodic syndrome is a rare autoinflammatory syndrome caused by a dysregulation of cytokine signaling pathways, particularly of the interleukin-1β production. Symptoms typical appear early in life and include recurrent fever, arthralgia, and cutaneous rash, often accompanied by systemic manifestations and progressive end-organ damage resulting from chronic inflammation. Interleukin- targeted therapy constitutes the basis for treatment, and can lead to complete resolution of symptoms. We report a case of a 66-year-old man with cryopyrin-associated periodic syndrome related to V198M mutation, successfully treated with anakinra, an interleukin- 1 inhibitor frequently used in rheumatoid arthritis.