AUTHOR=Yin Qinan , Huang Youjin , Wang Hulin , Wang Yin , Huang Xuefei , Song Yujie , Wang Yueyuan , Han Lizhu , Yuan Bian 

TITLE=COVID-19: a vascular nightmare unfolding

JOURNAL=Frontiers in Immunology

VOLUME=Volume 16 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2025.1593885

DOI=10.3389/fimmu.2025.1593885

ISSN=1664-3224

ABSTRACT=The emergence of COVID-19 has been associated with an increased risk of arteriovenous thrombosis, with immune inflammation playing a significant role in the pathogenesis of thrombosis. Numerous drug-related clinical trials have been undertaken to prevent thrombosis, and guidelines for its prevention and treatment are continuously evolving as our understanding of the disease progresses. This article provides a comprehensive review of the mechanisms underlying thrombosis in COVID-19 patients, as well as the advancements in clinical trials and guidelines for thrombosis prevention with pharmacological interventions.