AUTHOR=Mamede Lúcia , Sabà Roser Cantenys , Van Coillie Samya , Prévot Johan , Sánchez-Ramón Silvia , Poli Cecilia , Barasa Anne , Schuller Björn W. , Hendel Ayal , Garcelon Nicolas , Boersma Cornelis , Lee Pamela , Booth Claire , Notarangelo Luigi D. , Drabwell Jose , Rider Nicholas L. , Staal Frank J. T. , Burns Siobhan O. , Van Hagen Martin , Pergent Martine , Rivière Jacques G. , Mahlaoui Nizar 

TITLE=Navigating disruption in the PID landscape: embracing opportunities and anticipating threats in the next ten years

JOURNAL=Frontiers in Immunology

VOLUME=Volume 16 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2025.1596971

DOI=10.3389/fimmu.2025.1596971

ISSN=1664-3224

ABSTRACT=IntroductionThe International Patient Organisation for Primary Immunodeficiencies (IPOPI) held its third edition of the Global Multi-Stakeholders’ Summit, gathering key primary immunodeficiencies (PID) stakeholders and experts to discuss and foment global collaboration.MethodsThis edition focused on the impact of genomic medicine in PID treatment, the role of digital health, including artificial intelligence, in PID care, and how to anticipate and minimise risks to ensure optimal patient access to care.ResultsThese discussions aimed to examine current hurdles and brainstorm feasible solutions and priorities for the PID community in these areas in the next ten years.DiscussionThese discussions led to recommendations for comprehensive approaches to care and access to treatment for PID patients, suggesting actions that will bring the community closer to treatments based on real-world evidence and adjusted to patient’s needs. To accomplish this, collaboration between academia, industry, regulatory authorities, and patients is crucial.