AUTHOR=Tian Nan , Yang Yanwen , Liu Qiang , Ma Zeli , Wang Ying , Li Xuan , Wang Xu , Jin Yanzi , Chen Rong , Li Yajun , She Fenkui , Mou Fenglin , Zhang Qing 

TITLE=DKA with negative DM-autoantibodies, complicated by GBS and RESLES: a case report and literature review

JOURNAL=Frontiers in Immunology

VOLUME=Volume 16 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2025.1597365

DOI=10.3389/fimmu.2025.1597365

ISSN=1664-3224

ABSTRACT=Guillain-Barré syndrome (GBS) is an autoimmune-mediated disorder characterized by acute, multifocal peripheral neuropathies, typically triggered by infections, autoimmune diseases, or immunosuppressive therapies. In this report, we describe a patient newly diagnosed with diabetes mellitus (DM) and diabetic ketoacidosis (DKA), who presented with negative insulin-related autoantibodies and no identifiable infectious etiology. It is suggested that DKA may independently contribute to the development of GBS. Additionally, DKA can lead to the reversible splenial lesion syndrome (RESLES). We present a case of GBS with atypical features consistent with the acute motor axonal neuropathy (AMAN) variant.