AUTHOR=Yuan Qinghong , Cai Sirui , Chang Yuanhang , Zhang Junqi , Wang Meng , Yang Kun , Jiang Dongbo 

TITLE=The multifaceted roles of mucins family in lung cancer: from prognostic biomarkers to promising targets

JOURNAL=Frontiers in Immunology

VOLUME=Volume 16 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2025.1608140

DOI=10.3389/fimmu.2025.1608140

ISSN=1664-3224

ABSTRACT=Lung cancer remains one of the leading causes of cancer-related deaths worldwide, highlighting the urgent need for enhanced diagnostic and therapeutic strategies. Mucins, a family of glycoproteins crucial for maintaining epithelial integrity and regulating immune responses, have emerged as promising biomarkers and therapeutic targets in the context of lung cancer. The expression patterns and functional roles of mucin family members significantly influence lung cancer progression, thereby shaping diagnostic and therapeutic approaches for this disease. A more detailed classification of mucin family members could facilitate diagnosis and patient assessments, as well as help identify potential therapeutic targets. This review thoroughly examines the latest advancements in understanding the role of mucins in lung cancer progression, prognosis, and treatment, while also highlighting knowledge gaps and opportunities for future research, thus providing new perspectives for the management of this disease.