AUTHOR=Wang Dandan , Rong Hao , Ma Ke , Peng Jun 

TITLE=Lactylation in tumor: mechanisms and therapeutic potentials

JOURNAL=Frontiers in Immunology

VOLUME=Volume 16 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2025.1609596

DOI=10.3389/fimmu.2025.1609596

ISSN=1664-3224

ABSTRACT=Lactate, a central product of glucose metabolism, plays a vital role in energy supply and signal transduction, and it also participates in gene transcription regulation through lactylation. Metabolic reprogramming is a key feature of tumor cells and highlights the important role of lactylation in cancer development. Recent studies have emphasized the significant regulatory roles of lactylation in cancer, suggesting that it may serve as a potential target for treatment. This review discusses the mechanisms, regulation, and functions of lactylation in cancer. It also explores the possible significance of lactylation as a marker for the diagnosis and therapy of tumor, and evaluates the therapeutic prospects of targeting lactylation. While the precise mechanisms of lactylation in cancer regulation require further investigation, its significant influence indicates promising avenues for future research.