AUTHOR=Raj Desh , Verma Amit K. , Mathur Risha , Woody Jenna , Kathania Mahesh , Venuprasad K. 

TITLE=Fine-tuning immunity: ubiquitin-dependent regulation of interleukin-17A expression by Th17 cells

JOURNAL=Frontiers in Immunology

VOLUME=Volume 16 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2025.1614409

DOI=10.3389/fimmu.2025.1614409

ISSN=1664-3224

ABSTRACT=Interleukin-17A (IL-17A) is a pro-inflammatory cytokine that plays a pivotal role in immune responses, particularly in the pathogenesis of various autoimmune diseases and infections. Recent advances have highlighted the significance of post-translational modifications, particularly ubiquitination, in regulating IL-17A expression and IL-17A receptor signaling pathways. Here, we summarize the intricate relationship between IL-17A and ubiquitination, exploring how ubiquitin-mediated processes influence IL-17A production, receptor signaling, and downstream effector functions. We provide insights into the potential therapeutic implications of targeting IL-17A and its ubiquitination pathways in inflammatory diseases and autoimmune disorders. A clear understanding of this relationship could pave the way for novel strategies in immune modulation, potentially enhancing management and treatment efficacy in various human diseases.