AUTHOR=Zhang Yu , Guan Haixia , Feng Xixuan , Liu Mengyan , Shao Jinhuan , Liu Mengchi , He Jialei , Jin Yahui , Zhu Jinglin , Zheng Chunli 

TITLE=Emerging strategies in colorectal cancer immunotherapy: enhancing efficacy and survival

JOURNAL=Frontiers in Immunology

VOLUME=Volume 16 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2025.1616414

DOI=10.3389/fimmu.2025.1616414

ISSN=1664-3224

ABSTRACT=Colorectal cancer (CRC) is a prevalent malignancy of the digestive system, with metastatic CRC (mCRC) exhibiting persistently poor overall survival rates. Consequently, there is an urgent need to develop more effective and safer therapeutic strategies. In recent years, immunotherapy has emerged as a groundbreaking approach in CRC treatment. This review highlights the advancements in immune checkpoint Inhibitors (ICIs), cancer vaccines, oncolytic virotherapy, adoptive cell therapy(ACT), and matrix-depletion therapy. Additionally, we explore potential combinatorial immunotherapy strategies for CRC, emphasizing their clinical applications and addressing the challenges associated with CRC immunotherapy. By proposing strategies to overcome these limitations, this review aims to provide novel insights into the evolving landscape of CRC immunotherapy.