AUTHOR=Xie Wei , Chen Peijue , Luo Lili 

TITLE=Case Report: A patient presenting primarily with psychosis of NPSLE treated with telitacicept, corticosteroids, and immunosuppressants

JOURNAL=Frontiers in Immunology

VOLUME=Volume 16 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2025.1626721

DOI=10.3389/fimmu.2025.1626721

ISSN=1664-3224

ABSTRACT=Therapeutic strategies for neuropsychiatric systemic lupus erythematosus (NPSLE) primarily target underlying pathogenic mechanisms and typically include corticosteroids, immunosuppressants, anticoagulation, and adjunctive treatments. B-cell–targeted biologics are an emerging option for NPSLE. Although telitacicept is approved for systemic lupus erythematosus (SLE) treatment in China, evidence supporting its use in NPSLE remains limited. This case report presents a 20-year-old female diagnosed with NPSLE who exhibited psychotic symptoms as the predominant manifestation and was treated with telitacicept, corticosteroids, and immunosuppressants. During the treatment period, her psychiatric symptoms remained in remission without infections or adverse events. Her disease activity score (SLEDAI-2000) declined from 23 to 2.