AUTHOR=Almanzar Giovanni , Alarcon Juan Carlos , Garzon Ruth , Navarro Ana Maria , Ondo-Méndez Alejandro , Prelog Martina 

TITLE=Hypoxia and activation of hypoxia inducible factor alpha as influencers of inflammatory helper T cells in autoimmune disease – a link between cancer and autoimmunity

JOURNAL=Frontiers in Immunology

VOLUME=Volume 16 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2025.1633845

DOI=10.3389/fimmu.2025.1633845

ISSN=1664-3224

ABSTRACT=As a part of the tumor microenvironment, hypoxia is an important hallmark in the tumor progression. Hypoxia is a condition in which the oxygen supply is not sufficient to sustain the cell demand. In addition to its known impact in tumor progression, hypoxia seems to play a principal role in the generation and evolution of several autoimmune diseases. Both tumor and autoimmune diseases can be modulated by the hypoxia inducible factor alpha (HIF-1α) sharing similar molecular mechanisms. Here, we outline the links between cancer and autoimmunity regarding hypoxia-induced factors, such as HIF-1α, and describe the role of hypoxia in the modulation of the autoimmune response.