AUTHOR=Ohta Eri , Yamamoto Kayo , Fujimura Hitomi , Saito-Sasaki Natsuko , Okada Etsuko , Sawada Yu 

TITLE=Case Report: Severe neutropenia induced by avelumab in a patient with Merkel cell carcinoma

JOURNAL=Frontiers in Immunology

VOLUME=Volume 16 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2025.1672282

DOI=10.3389/fimmu.2025.1672282

ISSN=1664-3224

ABSTRACT=A 78-year-old woman with a history of follicular lymphoma treated with obinutuzumab and bendamustine developed Merkel cell carcinoma (MCC) on her left forearm. After surgical excision, in-transit and lymph node metastases appeared within three weeks. Avelumab and radiotherapy were initiated, but severe neutropenia occurred after two doses, requiring G-CSF support and treatment discontinuation. Despite early cessation, metastatic lesions regressed. This case suggests that prior B-cell–directed therapy may increase the risk of hematologic toxicity with immune checkpoint inhibitors and that even short-term avelumab may induce a durable response in MCC.