AUTHOR=Pennesi Giuseppina TITLE=Editorial: Genes, cells, and macroenvironments: regulating the immune response in extreme conditions JOURNAL=Frontiers in Immunology VOLUME=Volume 16 - 2025 YEAR=2025 URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2025.1674347 DOI=10.3389/fimmu.2025.1674347 ISSN=1664-3224