AUTHOR=Chen Yu , Wen Wenjie , Wang Jie , Huang Shiting , Ren Qianqian , Cai Jiayao , Zhou Songlin , Li Rui , Ren Dandan , Peng Liaotian , Deng Chao , Zhang Jue 

TITLE=Modified recombinant collagen-peptide/gallic acid grafted chitosan composites with antibacterial and antioxidant property for wound dressing: a preliminary study

JOURNAL=Frontiers in Immunology

VOLUME=Volume 16 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2025.1675212

DOI=10.3389/fimmu.2025.1675212

ISSN=1664-3224

ABSTRACT=Chronic wounds pose a persistent clinical challenge, primarily due to prolonged bacterial infections. The development of natural antibacterial dressings offers a promising strategy for their effective management. In this study, recombinant human collagen methacrylamide (RHCMA) and gallic acid-grafted chitosan (CSGA) were synthesized and subsequently crosslinked via UV irradiation to form a composite hydrogel (RHCMA-CSGA). The composition and structure of the hydrogel were systematically characterized. Its cytocompatibility and antibacterial properties were also evaluated. The results demonstrated that the hydrogel exhibited excellent biocompatibility and strong antibacterial activity. These findings suggest that the RHCMA-CSGA hydrogel holds great potential as a therapeutic dressing for chronic wound healing.