Frontiers in Immunology

Original Research

Published on 28 Apr 2025

Moderate toxicity with late onset as a good omen: association between toxicity and survival in the checkpoint inhibitor immunotherapy—a single center experience

in Cancer Immunity and Immunotherapy

Anna Rudzińska
Pola Juchaniuk
Jakub Oberda
Kamila Krukowska
Sylwia Krzyśkowska
Eliza Kuchta
Anna Rodzajewska
Mariola Janiszewska
Katarzyna Machulska-Ciuraj
Katarzyna Szklener

Frontiers in Immunology

doi 10.3389/fimmu.2025.1527103

303 views

Original Research

Published on 28 Apr 2025

An immune cell activation signature reflected hepatocellular carcinoma heterogeneity and predicted clinical outcomes

in Cancer Immunity and Immunotherapy

Xiaofeng Wang
Dongli Liu
Shuai Wang
Rui He

Frontiers in Immunology

doi 10.3389/fimmu.2025.1534611

180 views

Review

Published on 28 Apr 2025

Systemic lupus erythematosus and atherosclerosis: immune pathways and the uncharted territory of gut microbiota and metabolism

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Quanren Pan
Xuemei Huang
Chaobin Liu
Qingjun Pan
Shian Huang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1492726

247 views

Review

Published on 28 Apr 2025

Revealing the mechanisms and therapeutic potential of immune checkpoint proteins across diverse protein families

in Cancer Immunity and Immunotherapy

Ran Liu
Xinyan Jiang
Ruijuan Dong
Yuting Zhang
Cong Gai
Peng Wei

Frontiers in Immunology

doi 10.3389/fimmu.2025.1499663

314 views

Original Research

Published on 28 Apr 2025

Association between plasma odd-chain fatty acid levels and immune cell traits in psoriasis: insights from a prospective cohort study

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Rongcan Shi
Yifei Xu
Xingyu Jiang
Bo Yu
Rui Ma
Xin Wang
Yuling Shi

Frontiers in Immunology

doi 10.3389/fimmu.2025.1500722

324 views

Review

Published on 28 Apr 2025

Epigenetic regulation in oogenesis and fetal development: insights into m6A modifications

in Inflammation

Lusheng Liu
Danxia Ge
Yumeng Lin
Zhongyu Han
Heng Zhao
Liqin Cao
Xi Wu
Guizhi Ma

Frontiers in Immunology

doi 10.3389/fimmu.2025.1516473

271 views

Original Research

Published on 28 Apr 2025

In vitro study: HIF-1α-dependent glycolysis enhances NETosis in hypoxic conditions

in Cancer Immunity and Immunotherapy

Yi Ye
Yanjun Wang
Qiying Xu
Juanli Liu
Ziqi Yang
Tana Wuren
Ri-Li Ge

Frontiers in Immunology

doi 10.3389/fimmu.2025.1583587

317 views

Mini Review

Published on 28 Apr 2025

Mystery machine: the complex roles of NLRX1 in viral infection

in Inflammation

Mackenzie K. Woolls
Carley M. Elliott
Hannah M. Ivester
Irving Coy Allen

Frontiers in Immunology

doi 10.3389/fimmu.2025.1581313

269 views

Review

Published on 28 Apr 2025

Crosstalk between the tumor immune microenvironment and metabolic reprogramming in pancreatic cancer: new frontiers in immunotherapy

in Cancer Immunity and Immunotherapy

Jintai Shi
Xiaoyan Cui
Junlin Wang
Guangqia Liu
Jiayin Meng
Yingjie Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1564603

215 views

Original Research

Published on 28 Apr 2025

Cannabidiol and nano-selenium mediate intestinal barrier function by affecting mucosal microstructures, and gut-associated immunological and oxidative stress response in the gut of chickens infected with C. perfringens

in Nutritional Immunology

Dominika Szkopek
Marta Mendel
Misza Kinsner
Katarzyna Ognik
Natalia Szyryńska
Bogdan Lewczuk
Krzysztof Kozłowski
Ivica Kos
Paweł Konieczka

Frontiers in Immunology

doi 10.3389/fimmu.2025.1529449

803 views

Review

Published on 28 Apr 2025

Deuterated water (2H2O, heavy water) labelling to investigate human cell dynamics in vivo - lessons in protocol design and toxicity from the current literature

in Immunological Memory

Ami Song
Yan Zhang
Robert Busch
Becca Asquith
Derek Macallan

Frontiers in Immunology

doi 10.3389/fimmu.2025.1544193

321 views

Opinion

Accepted on 25 Apr 2025

Spatiotemporal Imaging of Immune Dynamics: Rethinking Drug Efficacy Evaluation in Cancer Immunotherapy

in Cancer Immunity and Immunotherapy

Xiaowei Zhang
Chen Cheng
Xiaoyang Qu
Pengyun Wang
Dawei Zhang
Shuhong Dai

Frontiers in Immunology

doi 10.3389/fimmu.2025.1609606

453 views

Review

Accepted on 25 Apr 2025

Spatial Proteomics of the Tumor Microenvironment in melanoma: Current Insights and Future Directions

in Cancer Immunity and Immunotherapy

Chiara Bungaro
Michele Guida
Benedetta Apollonio

Frontiers in Immunology

doi 10.3389/fimmu.2025.1568456

403 views

Original Research

Accepted on 25 Apr 2025

Predominant T-cell epitopes of SARS-CoV-2 restricted by multiple prevalent HLA-B and C allotypes in Northeast Asia

in Viral Immunology

Yu Zhao
Min Peng
Chengtao He
Min Li
Xuelian Han
Qiang Fu
Yandan Wu
Yue Fangping
Chunguang Yan
Guangyu Zhao

Frontiers in Immunology

doi 10.3389/fimmu.2025.1545510

147 views

Original Research

Accepted on 25 Apr 2025

Comprehensive transcriptome assessment in PBMCs of post-COVID patients at a median follow-up of 28 months after a mild COVID infection reveals upregulation of JAK/STAT signaling and a prolonged immune response

in Viral Immunology

Serena Fineschi
Joakim Klar
Juan Ramon López-Egido
Jens Schuster
Jonas Bergquist
René Kaden
Niklas Dahl

Frontiers in Immunology

doi 10.3389/fimmu.2025.1589589

125 views

Editorial

Accepted on 25 Apr 2025

Exploring Macrophage Roles in Cancer Progression and Therapeutic Targeting

in Cancer Immunity and Immunotherapy

David Entenberg
George S Karagiannis
Yu Kato

Frontiers in Immunology

doi 10.3389/fimmu.2025.1612588

155 views