Frontiers in Immunology | New and Recent Articles https://www.frontiersin.org/journals/immunology RSS Feed for Frontiers in Immunology | New and Recent Articles en-us Frontiers Feed Generator,version:1 2026-05-12T20:57:01.290+00:00 60 https://www.frontiersin.org/articles/10.3389/fimmu.2026.1792836 https://www.frontiersin.org/articles/10.3389/fimmu.2026.1792836 <![CDATA[Multi-omics investigation of perineural invasion in head and neck squamous cell carcinoma: neuroimmune mechanisms and clinical implications]]> 2026-05-12T00:00:00Z Original Research Muling DengYuhao LinChenyu FangJiaqi CaiChuanben ChenJianming Ding https://www.frontiersin.org/articles/10.3389/fimmu.2026.1752217 https://www.frontiersin.org/articles/10.3389/fimmu.2026.1752217 <![CDATA[Temporal transcriptional dynamics in cutaneous leishmaniasis reveal novel targets for therapeutic interventions in a dermal mouse model]]> 2026-05-12T00:00:00Z Original Research Jessica Lobo-SilvaCibele OrgeAlmiro Pires da Silva NetoBruno Vinagre RibeiroRegiane Degan FávaroJoyce Karoline da SilvaSara Patrícia de Oliveira SantosSara NunesValdomiro Silveira Moitinho-JuniorAldina BarralNatalia Tavares MachadoPablo Ivan Pereira RamosRicardo KhouriLeonardo Paiva Farias https://www.frontiersin.org/articles/10.3389/fimmu.2026.1767380 https://www.frontiersin.org/articles/10.3389/fimmu.2026.1767380 <![CDATA[Induction immunochemotherapy followed by concurrent chemoradiotherapy improves survival in unresectable esophageal cancer: a systematic review, meta-analysis, and network meta-analysis]]> 2026-05-12T00:00:00Z Systematic Review Xuefei FanXin LiuSong MiYunxin YangChenggong LiJiandong ZhangPingping Hu https://www.frontiersin.org/articles/10.3389/fimmu.2026.1803188 https://www.frontiersin.org/articles/10.3389/fimmu.2026.1803188 <![CDATA[Predictive value of thyroid autoantibodies for coronary heart disease severity in individuals with normal thyroid function based on machine learning and SHAP interpretation]]> 2026-05-12T00:00:00Z Original Research Nana LiangHuiru MaXingyue WangJie MengZixuan RuNa LvKerou LiHong Qiao https://www.frontiersin.org/articles/10.3389/fimmu.2026.1756194 https://www.frontiersin.org/articles/10.3389/fimmu.2026.1756194 <![CDATA[Treg-derived IFN-γ supports the differentiation of Th1-Treg in tumor immunity and autoimmunity]]> 2026-05-12T00:00:00Z Original Research Ayumi KurataniMasaaki OkamotoSekar ArumsariTakashi KobayashiMiwa SasaiMasahiro Yamamoto https://www.frontiersin.org/articles/10.3389/fimmu.2026.1708062 https://www.frontiersin.org/articles/10.3389/fimmu.2026.1708062 <![CDATA[Case Report: IgG4-rich tubulointerstitial inflammation in MPO-ANCA-associated glomerulonephritis: a case-based review]]> 2026-05-12T00:00:00Z Case Report Songlin QiuSufen LiMinya JinYijun ChenSuyun Chen https://www.frontiersin.org/articles/10.3389/fimmu.2026.1770276 https://www.frontiersin.org/articles/10.3389/fimmu.2026.1770276 <![CDATA[CD73 activity controls cytotoxic CD4 T-cell response driving myocardial pathology in chronic Chagas disease]]> 2026-05-12T00:00:00Z Original Research Gastón BergeroYanina L. MazzoccoZoé M. Cejas GallardoWalter RivarolaSebastian Del RossoMaria P. Aoki https://www.frontiersin.org/articles/10.3389/fimmu.2026.1818962 https://www.frontiersin.org/articles/10.3389/fimmu.2026.1818962 <![CDATA[The biological characteristics of tertiary lymphoid structures in head and neck cancer]]> 2026-05-12T00:00:00Z Review Suwen BaiYuan WeiFankai LiuHexing SunXianhai ZengPeng Zhang https://www.frontiersin.org/articles/10.3389/fimmu.2026.1835853 https://www.frontiersin.org/articles/10.3389/fimmu.2026.1835853 <![CDATA[Case Report: Cytokine storm syndrome causing retinal inflammatory factor storm]]> 2026-05-12T00:00:00Z Case Report Na LiuJingyi BaiGaixia ZhaiShaopeng Wang https://www.frontiersin.org/articles/10.3389/fimmu.2026.1738865 https://www.frontiersin.org/articles/10.3389/fimmu.2026.1738865 <![CDATA[Real-world comparison of anti-CD20 therapies: efficacy, infections, and immune profiles in a German cohort]]> 2026-05-12T00:00:00Z Original Research Jakob StögbauerMoritz BewarderLinda GroßLorenz ThurnerKlaus FassbenderRebecca UrschelEinar A. HøgestølGro O. NygaardHanne F. HarboOlaf StüveMarc PawlitzkiSven G. MeuthMartina SesterSergiu GroppaMathias Fousse https://www.frontiersin.org/articles/10.3389/fimmu.2026.1761552 https://www.frontiersin.org/articles/10.3389/fimmu.2026.1761552 <![CDATA[Pregnane X receptor (NR1I2) deficiency in mice reveals context-dependent regulation of inflammatory homeostasis]]> 2026-05-12T00:00:00Z Review Salah Edden Amini https://www.frontiersin.org/articles/10.3389/fimmu.2026.1774959 https://www.frontiersin.org/articles/10.3389/fimmu.2026.1774959 <![CDATA[Deciphering the mechanistic landscape of immune checkpoint blockade in ccRCC: from molecular drivers to therapeutic responses]]> 2026-05-12T00:00:00Z Review Lingxiang RanGuangmo HuChunyu FanYuanyin TengRui ZhaoQinghua LiJing-Min YangChao Zhang https://www.frontiersin.org/articles/10.3389/fimmu.2026.1791460 https://www.frontiersin.org/articles/10.3389/fimmu.2026.1791460 <![CDATA[Age-related and disease-specific changes in B-cell profiles in older adults with immune thrombocytopenia]]> 2026-05-12T00:00:00Z Brief Research Report E. Monzón ManzanoC. Herrero CarrascoP. AcuñaL. del Pino MolinaE. G. Arias-SalgadoA. MendozaR. KapurL. PorcelijnM. Martín SalcesM. I. Rivas PollmarE. López-GranadosV. Jiménez YusteM. Gasior KabatR. Ramírez MartínN. ButtaM. T. Álvarez Román 65) and aged 65 or under (ITP ≤ 65). These ITP groups were compared with age-matched healthy controls to determine whether the observed differences were due to the disease itself or the effects of ageing.MethodsBlood samples were processed and stained using the EuroFlow 8-colour PIDOT and pre-germinal centre B-cell tubes, following the EuroFlow SOPs for staining cell surface membrane markers.ResultsPatients with ITP>65, compared with those ≤65, showed reduced immature/transitional B cell subsets, an increased population of CD21-CD24- naïve B cells, and higher plasma B-cell activating factor levels. Comparison of the ITP ≤ 65 group with the HC ≤ 65 group showed that patients with ITP had a lower B-cell count, but a significant increase in the CD21-CD24- naïve B-cell subset. Patients with ITP>65 had expanded CD21-CD24- and CD21-CD24++ naïve and memory IgMD+ B-cell populations compared to the HC>65 group.ConclusionThese findings suggest that ageing induces modifications to the B-cell phenotype that are similar to those observed in patients with ITP, except for the expansion of the CD21-CD24- naïve B-cell subset, which appears to be a characteristic of ITP shared with other autoimmune diseases.]]> https://www.frontiersin.org/articles/10.3389/fimmu.2026.1806683 https://www.frontiersin.org/articles/10.3389/fimmu.2026.1806683 <![CDATA[Immunological mechanisms and precision stratification in male infertility: from testicular immune privilege and danger signal amplification to seminal immune biomarkers and mechanism-tailored intervention]]> 2026-05-12T00:00:00Z Review Jiedong ZhouShian HuYong OuyangDong YangZhi SuMin Liu https://www.frontiersin.org/articles/10.3389/fimmu.2026.1818121 https://www.frontiersin.org/articles/10.3389/fimmu.2026.1818121 <![CDATA[Therapeutic cancer vaccines: navigating clinical translation and multimodal synergy]]> 2026-05-12T00:00:00Z Review Tan-Huy ChuThuy Linh HuynhLe-Tri Phuong https://www.frontiersin.org/articles/10.3389/fimmu.2026.1814357 https://www.frontiersin.org/articles/10.3389/fimmu.2026.1814357 <![CDATA[AI-driven insights into protein misfolding and innate immunity in neurodegenerative diseases]]> 2026-05-12T00:00:00Z Review Hui Xin DengJing Ling CaoYao WuSi Jin JiangQian Qian FangBi Yue ZhuYong Jian Jiang https://www.frontiersin.org/articles/10.3389/fimmu.2026.1783098 https://www.frontiersin.org/articles/10.3389/fimmu.2026.1783098 <![CDATA[Early sex-related transcriptional differences in CD8+ T cells responding to chronic viral infection reveal a sex bias in exhaustion]]> 2026-05-12T00:00:00Z Original Research Nyambura KahiaSean M. RobertsonMegan RodriguezPaul Jerard LayugHarman VatsKamali KannanVictor SpicerArzu Ozturk-AptekmannOlivia WilkinsJanilyn Arsenio https://www.frontiersin.org/articles/10.3389/fimmu.2026.1816695 https://www.frontiersin.org/articles/10.3389/fimmu.2026.1816695 <![CDATA[HDAC7 controls anti-viral and anti-tumor immunity by CD8+ T cells]]> 2026-05-12T00:00:00Z Original Research Cansu YerindeJacqueline KeyeHsiang-Jung HsiaoSibel DurlanikInka FreiseFranziska NowakMarilena LetiziaStephan SchlickeiserBenedikt ObermayerAdrian HuckMarie FriedrichHao WuDésirée KunkelAnja A. KühlSebastian BauerAndreas ThielAhmed N. HegazyBritta SiegmundRainer GlaubenCarl Weidinger https://www.frontiersin.org/articles/10.3389/fimmu.2026.1742723 https://www.frontiersin.org/articles/10.3389/fimmu.2026.1742723 <![CDATA[Unlocking the potential: current landscape and future directions of immunotherapy in gastric cancer]]> 2026-05-12T00:00:00Z Review Yingfei ZhouLuling WeiLuoyang WangBei ZhangJie Liang https://www.frontiersin.org/articles/10.3389/fimmu.2026.1793153 https://www.frontiersin.org/articles/10.3389/fimmu.2026.1793153 <![CDATA[Efficacy and safety of efgartigimod as an add-on therapy in patients with NMOSD and MOGAD at the acute attack phase]]> 2026-05-12T00:00:00Z Original Research Weifan YinShige WangWei LuTianjiao Duan