Frontiers in Immunology

Systematic Review

Published on 26 Jan 2026

Gut microbiota and postoperative complications in colorectal surgery and its potential association with intestinal permeability and NLRP6 inflammasome

in Inflammation

Manuel Buitrago-Ruiz
Celia Arias-Sánchez
Maria Magdalena Asensio-López
Juan José Martínez-García
Victoriano Soria-Aledo
Graciela Valero-Navarro
Santiago Cuevas

Frontiers in Immunology

doi 10.3389/fimmu.2025.1701650

434 views

Original Research

Published on 26 Jan 2026

Repetitive transcranial magnetic stimulation alleviates neuropathic pain via microglial polarization by modulating the METTL3/NMDAR2B/NLRP3 pathway

in Inflammation

Jiayi Zhu
Lei Li
Rongnan Shi
Fei Xing
Yue Yang
Zhangyu Xu
Qin Wang
Qi Deng
Dan Li
Maomao Huang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1666920

633 views

Original Research

Published on 23 Jan 2026

TLR3 and GLUL orchestrate inflammatory and homeostatic imbalance in osteoarthritis

in Inflammation

Jing Wang
Shenghao Xu
Bo Chen
Peiqiang Peng
Kai Wang
Yanguo Qin

Frontiers in Immunology

doi 10.3389/fimmu.2025.1650375

739 views

Clinical Trial

Published on 23 Jan 2026

POLB 001, a p38 MAPK inhibitor, decreases local and systemic inflammatory responses following in vivo LPS administration in healthy volunteers: a randomised, double-blind, placebo-controlled study

in Inflammation

Digna T. de Bruin
Manon A. A. Jansen
Diana R. Pereira
Lisa van Schijndel
Erica S. Klaassen
Marije E. Otto
Jeremy Skillington
Paula Maguire
Liam Tremble
Alan Bell

Frontiers in Immunology

doi 10.3389/fimmu.2025.1684307

2,048 views

Original Research

Accepted on 22 Jan 2026

S100A8/A9 Inhibition Reduces Splenic Myelopoiesis and Improves Outcomes After Stroke

in Inflammation

Hyun Ah Kim
Annas Al-sharea
Hannah X. Chu
Sung-chun Tang
Samoda A. Rupasinghe
Shenpeng Zhang
Prabhakara N Nagareddy
Grant Drummond
Thiruma Valavan Arumugam
Andrew J. Murphy

Frontiers in Immunology

173 views

Original Research

Accepted on 22 Jan 2026

Sex-associated transcriptional changes to synovial macrophages in the aging joint

in Inflammation

Matthew Dapas
Erica de Jong
Yidan Wang
Cally Mills
Samuel D. Dowling
Tyler Austin Therron
Samuel Dadd Hamilton
Carla Marie Cuda
Dawn M.E. Bowdish
Deborah R. Winter

Frontiers in Immunology

157 views

Original Research

Published on 22 Jan 2026

GDF15 orchestrates mitochondrial-immune crosstalk via SMAD7-HIF-1α-PKM2 cascade to attenuate septic liver injury

in Inflammation

Xiandong Kuang
Zhili Niu
Wenqiang Liu
Zhaoyang Huang
Shuo Li
Ye Zhang
Li Wang
Xin Cai
Faxi Wang
Pingan Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1712741

665 views

Original Research

Published on 22 Jan 2026

Endogenous CD5L controls the metabolic and inflammatory state of human macrophages

in Inflammation

Kashif Rasheed
Neda Nejati Moharrami
Erlend Bjørkøy Tande
Terje Espevik
Maria Yurchenko
Victor Boyartchuk

Frontiers in Immunology

doi 10.3389/fimmu.2025.1677948

708 views

Brief Research Report

Published on 22 Jan 2026

Systemic inflammation is a risk factor for oral health: an analysis of data from the UK Biobank

in Inflammation

Martin Berger
Jaana-Sophia Kern
Ulrike Schulze-Späte
Stefan Wolfart
Joachim Jankowski
Michael Wolf
Nikolaus Marx
Katharina Marx-Schütt

Frontiers in Immunology

doi 10.3389/fimmu.2025.1651947

428 views

Original Research

Published on 22 Jan 2026

Fibroblasts as key effectors of acupuncture in treatment of rheumatoid arthritis

in Inflammation

Shi-Wei Tu
Jun Kawanokuchi
Ken Takagi
Yang-Yang Liu
Jun-Yi Li
Kai-Yuan Deng
Yan-Wei Li
Kai-Fang Yao
Zhi-Han Chen
Ze-Zhi Fan

Frontiers in Immunology

doi 10.3389/fimmu.2026.1715313

665 views

Review

Published on 22 Jan 2026

Multidimensional regulation of estrogen signaling in pelvic floor connective tissue homeostasis and remodeling

in Inflammation

Lin Wang
Mengyu Geng
Lingyun Wei
Shuyu Wang
Wenzhen Wang
Xiaochun Liu

Frontiers in Immunology

doi 10.3389/fimmu.2026.1742246

1,384 views

Original Research

Published on 22 Jan 2026

650 nm red-light therapy attenuates sepsis-induced acute lung injury via adiponectin-mediated immune–metabolic reprogramming

in Inflammation

Yiqiu Zhang
Wei Ni
Jianghan Li
Yubing Bai
Yier Bai
Zhixuan Jiang
Jiadie Wang
Yu He
Yafeng Li
Jing Yuan

Frontiers in Immunology

doi 10.3389/fimmu.2026.1710363

560 views

Original Research

Accepted on 21 Jan 2026

The Diagnostic and Immunomodulatory Role of IL-37 in Pediatric Sepsis

in Inflammation

Chunxiang Wu
Jin Ma
Yanling Zhang
Changrui Sun
Hao Yang
Zhixin Song
Feiqi Huang

Frontiers in Immunology

135 views

Review

Published on 21 Jan 2026

The interplay mechanisms between gut microbiota and ferroptosis in inflammatory bowel disease

in Inflammation

Zihan Shi
Shuyun Zhang
Hongru Zhai
Qingmin Wu
Yanyun Li
Huibin Xu
Shanlong Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2026.1753617

813 views

Review

Published on 21 Jan 2026

Cholinergic reflex control of inflammation: mechanistic and translational advances in transcutaneous auricular vagus nerve stimulation across rheumatic, metabolic, and postoperative disorders

in Inflammation

Rui Han
Zongbo Peng
Ming Zhuo
Yuanyuan Song
Yuhao Liu
Xiaowen Zhang
Zihao Deng
Lingyi Xia
Mao-Lin Zhong

Frontiers in Immunology

doi 10.3389/fimmu.2025.1702185

1,107 views

Original Research

Published on 21 Jan 2026

Berberine-taxifolin co-administration attenuates inflammatory response and intestinal barrier injury via nf-κB/NLRP3 suppression in colitis

in Inflammation

Ganggang Miao
De Zhang
Zhenghui Sui
Jianfei Leng
Yanxiang Deng
Xingwei Gu
Hongyong Cao

Frontiers in Immunology

doi 10.3389/fimmu.2025.1725084

541 views

Original Research

Published on 21 Jan 2026

A berberine-loaded hydrogel for the treatment of atopic dermatitis through antibacterial activity, inhibition of inflammation and modulation of oxidative stress

in Inflammation

Ze Peng
Xin-Yu Wei
Xin Zeng
Gulinigaer anwaier
Xun Zhou
Bing-Jun Shi

Frontiers in Immunology

doi 10.3389/fimmu.2026.1740911

856 views

Original Research

Accepted on 20 Jan 2026

Age-Associated Chemokine Receptor Expression Profiles in Human Peripheral Blood Monocyte Subsets Predict Cardiovascular Disease Risk

in Inflammation

Ravi K Komaravolu
Nandini Chatterjee
Sunil Kumar
Jessica L Allen
Christopher Durant
Runpei Wu
Gabriel Valentin-Guillama
Chantel McSkimming
Fabrizio Drago
Angela M. Taylor

Frontiers in Immunology

483 views

Original Research

Published on 20 Jan 2026

Pathological neutrophil extracellular traps hinder postoperative anal fistula wound healing and are attenuated by Zuoqing granule via suppression of the Nox4 pathway

in Inflammation

Xiaoli Fang
Heng Deng
Ming Li
Xiang Gao
Chunrong He
Hui Liu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1730184

811 views

Original Research

Published on 20 Jan 2026

Paeoniflorin attenuates sepsis-induced liver injury by reprogramming macrophage polarization via the TLR4/NF-κB pathway

in Inflammation

Zhiwei Rong
Baitian Li
Chunzheng Liu
Lijun Liao

Frontiers in Immunology

doi 10.3389/fimmu.2025.1751550

984 views

Original Research

Published on 20 Jan 2026

Shen-Hong-Tong-Luo formula ameliorates atherosclerosis by enhancing macrophage efferocytosis through activating the PPARγ/mfge8 pathway

in Inflammation

Yanyu Shi
Zepeng Zhang
Jiaqi Liu
Xiaolin Xu
Xue Xiao
Tianyang Zhang
Yuan Zhang
Haoran Cui
Xiangyan Li
Ying Chen

Frontiers in Immunology

doi 10.3389/fimmu.2025.1727378

957 views

Original Research

Published on 20 Jan 2026

Nrf2/HO-1–dependent inhibition of ferroptosis underlies the antioxidant effects of 5-O-methylvisammioside in colitis

in Inflammation

Donglin Li
Fagang Xu
Wei Wang
Chuan Jiang
Wenwen Cui
Zhong-an Guan
Chao Gu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1738408

660 views

Original Research

Accepted on 19 Jan 2026

Integrating Network Pharmacology, Microbiomics, and Metabolomics to Uncover the Therapeutic Effect of Liubao Tea on Osteoarthritis

in Inflammation

Le Guoping
Wen Riyou
Huang Zhifa
Fang Huaixi
Zheng Jianwei
Luo Hanwen

Frontiers in Immunology

174 views

Review

Accepted on 16 Jan 2026

Mechanisms and Therapeutic of Immunometabolic Reprogramming Driving Macrophage-Endothelial Cell Interactions in Sepsis-Associated ARDS from the Gut-Lung Axis Perspective

in Inflammation

Jia Tang
Mi Yan
Mengchun Li
Wanwei Li
Zhangxue Hu

Frontiers in Immunology

163 views

5,774 articles

articles

Gut microbiota and postoperative complications in colorectal surgery and its potential association with intestinal permeability and NLRP6 inflammasome

Repetitive transcranial magnetic stimulation alleviates neuropathic pain via microglial polarization by modulating the METTL3/NMDAR2B/NLRP3 pathway

TLR3 and GLUL orchestrate inflammatory and homeostatic imbalance in osteoarthritis

POLB 001, a p38 MAPK inhibitor, decreases local and systemic inflammatory responses following in vivo LPS administration in healthy volunteers: a randomised, double-blind, placebo-controlled study

S100A8/A9 Inhibition Reduces Splenic Myelopoiesis and Improves Outcomes After Stroke

Sex-associated transcriptional changes to synovial macrophages in the aging joint

GDF15 orchestrates mitochondrial-immune crosstalk via SMAD7-HIF-1α-PKM2 cascade to attenuate septic liver injury

Endogenous CD5L controls the metabolic and inflammatory state of human macrophages

Systemic inflammation is a risk factor for oral health: an analysis of data from the UK Biobank

Fibroblasts as key effectors of acupuncture in treatment of rheumatoid arthritis

Multidimensional regulation of estrogen signaling in pelvic floor connective tissue homeostasis and remodeling

650 nm red-light therapy attenuates sepsis-induced acute lung injury via adiponectin-mediated immune–metabolic reprogramming

The Diagnostic and Immunomodulatory Role of IL-37 in Pediatric Sepsis

The interplay mechanisms between gut microbiota and ferroptosis in inflammatory bowel disease

Cholinergic reflex control of inflammation: mechanistic and translational advances in transcutaneous auricular vagus nerve stimulation across rheumatic, metabolic, and postoperative disorders

Berberine-taxifolin co-administration attenuates inflammatory response and intestinal barrier injury via nf-κB/NLRP3 suppression in colitis

A berberine-loaded hydrogel for the treatment of atopic dermatitis through antibacterial activity, inhibition of inflammation and modulation of oxidative stress

Age-Associated Chemokine Receptor Expression Profiles in Human Peripheral Blood Monocyte Subsets Predict Cardiovascular Disease Risk

Pathological neutrophil extracellular traps hinder postoperative anal fistula wound healing and are attenuated by Zuoqing granule via suppression of the Nox4 pathway

Paeoniflorin attenuates sepsis-induced liver injury by reprogramming macrophage polarization via the TLR4/NF-κB pathway

Shen-Hong-Tong-Luo formula ameliorates atherosclerosis by enhancing macrophage efferocytosis through activating the PPARγ/mfge8 pathway

Nrf2/HO-1–dependent inhibition of ferroptosis underlies the antioxidant effects of 5-O-methylvisammioside in colitis

Integrating Network Pharmacology, Microbiomics, and Metabolomics to Uncover the Therapeutic Effect of Liubao Tea on Osteoarthritis

Mechanisms and Therapeutic of Immunometabolic Reprogramming Driving Macrophage-Endothelial Cell Interactions in Sepsis-Associated ARDS from the Gut-Lung Axis Perspective