Frontiers in Immunology | Viral Immunology

Original Research

Published on 18 Jun 2025

Immunopathological features of highly pathogenic Korean Lineage B PRRSV-2: insights into virulence indicators and host immune responses

in Viral Immunology

Gyeong-Seo Park
Seung-Chai Kim
Hwan-Ju Kim
Chang-Gi Jeong
Sang-Chul Kang
Go-Eun Shin
Seoung-Hee Kim
Hye-Young Jeong
Kyoung-Ki Lee
Sang-Myeong Lee

Frontiers in Immunology

doi 10.3389/fimmu.2025.1599468

3,543 views
2 citations

Editorial

Published on 17 Jun 2025

Editorial: Viral impact on CNS: mechanisms of immune dysfunction and cognitive decline

in Viral Immunology

Thomas A. Angelovich
Sonia Mediouni
Robyn S. Klein
Jacob D. Estes
Bruce J. Brew
Melissa J. Churchill

Frontiers in Immunology

doi 10.3389/fimmu.2025.1639948

2,083 views
1 citation

Original Research

Published on 16 Jun 2025

The role of innate immune responses against two strains of PEDV (S INDEL and non-S INDEL) in newborn and weaned piglets inoculated by combined orogastric and intranasal routes

in Viral Immunology

C. López-Figueroa
E. Cano
N. Navarro
M. Pérez
R. López
K. Skovgaard
H. Vorsholt
P. M. H. Heegaard
J. Vergara-Alert
J. Segalés

Frontiers in Immunology

doi 10.3389/fimmu.2025.1584785

2,526 views
1 citation

Original Research

Published on 16 Jun 2025

Cordycepin, lactoferrin, and Sargassum fusiforme polysaccharides protects against RSV via M2-like macrophage polarization

in Viral Immunology

Xiaozong Fu
Panwen Huang
Yuting Zhang
Yanchang Li
Shichang Hu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1576069

2,980 views
2 citations

Original Research

Published on 12 Jun 2025

The DEAD-box RNA helicase 27 negatively regulates the replication of porcine reproductive and respiratory syndrome virus by mediating GP2a autophagy degradation and inducing interferon-β production

in Viral Immunology

Binghua Chen
Yunyan Luo
Yongjie Chen
Jingxing Wang
Jiecong Yan
Zhan He
Fangfang Li
Chunhe Guo

Frontiers in Immunology

doi 10.3389/fimmu.2025.1587647

3,076 views
1 citation

Original Research

Published on 12 Jun 2025

Integrated bioinformatics analysis identifies hub genes and immune regulatory networks in HIV infection

in Viral Immunology

Xiaoxia Pang
Xinghong Chen
Yuxin Jing
Feng Shi
Xiaoying Chen
Huatuo Huang
Chunhong Liu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1600713

4,182 views
2 citations

Original Research

Published on 11 Jun 2025

Proteomic and metabolomic analysis of serum in women infected with COVID-19 during late pregnancy

in Viral Immunology

Yi Zheng
Jinyu Ning
Jiang Zhu
Honglin Zhu
Zhihua She
Pei Cai

Frontiers in Immunology

doi 10.3389/fimmu.2025.1589239

3,571 views
2 citations

Original Research

Published on 11 Jun 2025

Plasma proteomic profiling of hospitalized patients co-infected with HIV and SARS-CoV-2

in Viral Immunology

Xinyu Zhang
Xuan Yan
Jinfeng Sun
Yueming Shao
Wei Song
Tangkai Qi
Zhenyan Wang
Yang Tang
Jianjun Sun
Jingna Xun

Frontiers in Immunology

doi 10.3389/fimmu.2025.1601672

2,648 views
2 citations

Original Research

Published on 10 Jun 2025

Understanding the long-term interplay of SARS-CoV-2 immune and inflammatory responses with proteases in COVID-19 recovery: a longitudinal study

in Viral Immunology

Natalia Ćwilichowska-Puślecka
Aleksandra Makowiecka
Małgorzata Kalinka
Katarzyna Groborz
Tobiasz Puślecki
Marcin Drąg
Krzysztof Simon
Krystyna Dąbrowska
Monika Pazgan-Simon
Marcin Poręba

Frontiers in Immunology

doi 10.3389/fimmu.2025.1517933

5,084 views
2 citations

Original Research

Published on 10 Jun 2025

Sub-neutralizing levels of antibodies against RSV F protein enhance RSV infection via Fc-FcγR interactions

in Viral Immunology

Tingting Luo
Xin Zhao
Yi Lu
Wen Tan
Bingming Peng
Li Zhong
Jinhua Ma
Chenghao Mei
Huaqin Bu
Daiyin Tian

Frontiers in Immunology

doi 10.3389/fimmu.2025.1594937

4,079 views
2 citations

Original Research

Published on 06 Jun 2025

Dysregulated monocyte compartment in PACS patients

in Viral Immunology

Romy Kronstein-Wiedemann
Madeleine Teichert
Elisa Michel
Janina Berg
George Robinson
Kristin Tausche
Martin Kolditz
Johannes Bergleiter
Jessica Thiel
Dirk Koschel

Frontiers in Immunology

doi 10.3389/fimmu.2025.1613034

3,276 views

Original Research

Published on 06 Jun 2025

Whole-cell response of coronavirus-infected BMDCs through proteomic and transcriptomic analyses

in Viral Immunology

Yanxi Ji
Yuzhen Zhang
Yongjia Tong
Liu Cao
Lanyi Zeng
Yiran Xu
Xiao Guo
Tiefeng Xu
Zhidong Tang
Zhen Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1513952

3,102 views
1 citation

Original Research

Published on 04 Jun 2025

Novel NUDCD1 gene variant predisposes to severe COVID-19 disease in Asians through modulation of antiviral DHX15- and MAVS-mediated signalling

in Viral Immunology

Aseervatham Anusha Amali
Douglas Jie Wen Tay
Yiqi Seow
Marie Loh
Sharada Ravikumar
Jocelyn Jin Yu
Shaun Seh Ern Loong
Siew Wai Fong
Chang Jie Mick Lee
Jonathan Jordon Cailu Lim

Frontiers in Immunology

doi 10.3389/fimmu.2025.1581293

3,225 views

Original Research

Published on 04 Jun 2025

Cytokine secretion patterns distinguish herpes simplex virus type 2 meningitis from herpes simplex virus type 2 genital herpes

in Viral Immunology

Moa Bjerhem
Alexandra Svensson
Marie Studahl
Petra Tunbäck
Eva-Marie Boman
Kenny Brandström
Christine Lingblom
Azadeh Reyahi
Karolina Thörn
Kristina Eriksson

Frontiers in Immunology

doi 10.3389/fimmu.2025.1515741

2,341 views
1 citation

Original Research

Published on 03 Jun 2025

Silica-calcium phosphate nanoparticles delivering recombinant influenza hemagglutinin DNA can induce long-lasting T cell immune cross-protection in mice

in Viral Immunology

Xiaoxi Liu
Qingyu Wang
Yuhua Shi
Li Zhan
Lipeng Xu
Jiaru Hui
Kunpeng Xie
Chenxi Li
Chunjiang Li
Weiheng Su

Frontiers in Immunology

doi 10.3389/fimmu.2025.1572618

2,774 views

Review

Published on 30 May 2025

Proteome-wide characterization of PTMs reveals host cell responses to viral infection and identifies putative antiviral drug targets

in Viral Immunology

Xiaolu Li
Adam Kabza
Ashley N. Ives
Julianne Thiel
Katrina M. Waters
Wei-Jun Qian
Amy C. Sims
Tong Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1587106

4,700 views
4 citations

Original Research

Published on 30 May 2025

Comprehensive transcriptome assessment in PBMCs of post-COVID patients at a median follow-up of 28 months after a mild COVID infection reveals upregulation of JAK/STAT signaling and a prolonged immune response

in Viral Immunology

Serena Fineschi
Joakim Klar
Juan Ramon Lopez Egido
Jens Schuster
Jonas Bergquist
René Kaden
Niklas Dahl

Frontiers in Immunology

doi 10.3389/fimmu.2025.1589589

8,690 views
4 citations

Original Research

Published on 29 May 2025

Patrolling monocytes mediate virus neutralizing IgG effector functions: beyond neutralization capacity

in Viral Immunology

Abdelrahman Elwy
Swati Dhiman
Hossam Abdelrahman
Julia Specht
Theresa Charlotte Christ
Julia Falkenstein
Harpreet Kaur
Lisa Holnsteiner
Judith Lang
Matthias Mack

Frontiers in Immunology

doi 10.3389/fimmu.2025.1600056

2,561 views

Original Research

Published on 29 May 2025

Causal relationship between hepatic function indicators and thrombocytopenia risk in early-stage hepatitis B virus infection: evidence from clinical observational studies and mendelian randomization analyses

in Viral Immunology

Tian-bin Chen
Jian-wei Jiang
Hong-yan Guo
Xiao-tong Chen
Shuai Zhi
Yu-hai Hu
Ya Fu
Yong-bing Zeng
Can Liu
Qi-shui Ou

Frontiers in Immunology

doi 10.3389/fimmu.2025.1440317

3,891 views

Original Research

Published on 29 May 2025

Dynamic alterations of circulating lymphocytes during the trajectory of Hantaan virus-induced hemorrhagic fever with renal syndrome

in Viral Immunology

Lin Su
Shuangjuan Liu
Lei Shi
Yuan Cheng
Juanjuan Gao
Ruirui Guo
Yinli He
Linpei Zhang
Tianyan Chen
Jinsong Hu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1567306

2,481 views

Original Research

Published on 29 May 2025

A nomogram for predicting unfavorable outcomes of antituberculosis treatment among individuals with AIDS combined with pulmonary tuberculosis in China

in Viral Immunology

Xiaoxu Han
Jin Sun
Yuan Gao
Hongxia Yan
Xiangchuan He
Yuanyuan Ma
Peng Xu
Ning Ding
Xin Zhang
Meixin Ren

Frontiers in Immunology

doi 10.3389/fimmu.2025.1594107

2,879 views

Mini Review

Published on 23 May 2025

Mitochondrial metabolic rescue in post-COVID-19 syndrome: MR spectroscopy insights and precision nutritional therapeutics

in Viral Immunology

Li-zhen Chen
Qi Cai
Peng-fei Zheng

Frontiers in Immunology

doi 10.3389/fimmu.2025.1597370

8,964 views
8 citations

Original Research

Published on 22 May 2025

CD4+ T cell recognition of HIV-1 alternate reading frame proteins

in Viral Immunology

Joel Sop
Tyler P. Beckey
Joel N. Blankson

Frontiers in Immunology

doi 10.3389/fimmu.2025.1600132

2,016 views

Original Research

Published on 22 May 2025

Comparative analysis of neutrophil dynamics and disease in SARS-CoV-2 Delta and Omicron variants utilizing an in vivo feline model for COVID-19

in Viral Immunology

Sachithra Gunasekara
Shoroq Shatnawi
Sunil More
Breya Ludwig
Sai Narayanan
Miruthula Tamil Selvan
Craig A. Miller
Jennifer M. Rudd

Frontiers in Immunology

doi 10.3389/fimmu.2025.1547918

3,582 views