AUTHOR=Tighilet Brahim , mourre Christiane , Lacour Michel TITLE=Plasticity of the histamine H3 receptors after acute vestibular lesion in the adult cat JOURNAL=Frontiers in Integrative Neuroscience VOLUME=Volume 7 - 2013 YEAR=2014 URL=https://www.frontiersin.org/journals/integrative-neuroscience/articles/10.3389/fnint.2013.00087 DOI=10.3389/fnint.2013.00087 ISSN=1662-5145 ABSTRACT=
After unilateral vestibular neurectomy (UVN) many molecular and neurochemical mechanisms underlie the neurophysiological reorganizations occurring in the vestibular nuclei (VN) complex, as well as the behavioral recovery process. As a key regulator, the histaminergic system appears to be a likely candidate because drugs interfering with histamine (HA) neurotransmission facilitate behavioral recovery after vestibular lesion. This study aimed at analyzing the post-lesion changes of the histaminergic system by quantifying binding to histamine H3 receptors (H3R; mediating namely histamine autoinhibition) using a histamine H3 receptor agonist ([3H]N-α-methylhistamine). Experiments were done in brain sections of control cats (